Of course when you look at the individual biomarkers you find everything within whisper distance of 1.
The real takeaway from this study... Do not use these markers as screening tools. They may very likely be useful for diagnosis. They are not useful to identify pre symptomatic individuals.
The RR of 19 is not discussed in the actual article but appears to have been extricated after the fact. There is a chart that attempts to sum the RRs from the 4, but those RRs are still in the < 2 range...
I woke up this morning realizing why that 19 was causing such a tick if my psyche... It was not in the paper. It was extracted by a summarizer by dividing 288 by 15. 288 deaths in the upper quintile vs 15 in the lower. But the epidemiologists specifically DID not report this in the paper. The RR for all deaths for those 4 biomarkers was 1.75.
1.75 might be considered a little more than a whisper away from one. Let's call it a gentle cough. It is still very much in the zone of "I ain't worrying about this!"
I need to print out this study and keep it handy if ever I get a full physical again.
This story has gained more hits because of it's ties to Heinlein's "Lifeline".